HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 577744Generated: October 31, 2026
Ammonium Chloride → 4-amino-3-methyl-1H-Pyrazole-1-acetonitrile
https://huagongshe.com/reaction/577744
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | (3-Methyl-4-nitro-1H-pyrazol-1-YL)acetonitrile | HCID 19620685 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-amino-3-methyl-1H-Pyrazole-1-acetonitrile | HCID 86679673 | 20.6% |
Reaction Steps
A mixture of (3-methyl-4-nitro-1H-pyrazol-1-yl)acetonitrile (2.6 g, 15.7 mmol), NH4Cl (3.4 g, 62.7 mmol) and Fe powder (3.5 g, 62.7 mmol) in MeOH (60 mL) and water (12 mL) was stirred at 80° C. for 2 days. The mixture was filtered, concentrated and the residue was purified by flash chromatography (MeOH: CH2Cl2 20:1) to give the title compound (440 mg, 15% yield) as brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09040547B2 |
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| Source dataset | uspto-grants-2015_05 |
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| ORD ID | ord-616e9d627a014a508b830f9e3eac7751 |
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| Source note | uspto-grants-2015_05 |
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