HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-nitro-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole → 1-(Tetrahydro-2H-pyran-4-YL)-1H-pyrazol-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-nitro-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole | HCID 59186296 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(Tetrahydro-2H-pyran-4-YL)-1H-pyrazol-4-amine | HCID 51063703 | 95.1% |
Reaction Steps
A solution of 4-nitro-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole (568 mg, 2.88 mmol, 1 equiv) in methanol was circulated through a H-Cube® Continuous-flow hydrogenation reactor (ThalesNano) fitted with a palladium on carbon catalyst cartridge at 50° C. The collected solution was concentrated in vacuo to afford product as pink solid (458 mg, 95% yield). LCMS (ESI) m/z: 168.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434732B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-70bae89315f14c35bf0aa6bb6e2e96bd |
| Source note | uspto-grants-2016_09 |