HCID 86679681, compound → HCID 86679682, compound

Participants

Reaction Steps

To a solution of tert-butyl(cis)-5-benzyl-3a-methoxyhexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate (185 mg, 0.556 mmol) in EtOH (5.5 mL) purged with nitrogen was added Pd(OH)2/C (78 mg) and stirred under H2 (balloon) for 18 hrs. The reaction mixture was filtered and concentrated under reduced pressure to afford the title compound (128 mg, 95% yield). 1H NMR (400 MHz, chloroform-d) δ ppm 3.83-4.02 (m, 1H) 3.38-3.80 (m, 5H) 3.34 (s, 3H) 3.14-3.33 (m, 2H) 2.78-3.05 (m, 2H) 1.47 (s, J=2.57 Hz, 9H); m/z (APCI+) for C12H22N2O3 243.20 (M+H)+.

Provenance & Evidence