HCID 178464473, compound → HCID 178464475, compound

HRID 577803Notes

Reaction equation

CN(C)C(=O)C[CH2:5][N:6]([CH3:35])[C:7]1[CH:12]=[CH:11][C:10]([NH:13]/[C:14](/[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[C:15]2\[C:16](=[O:28])[NH:17][C:18]3[C:23]\2=[CH:22][CH:21]=[C:20]([C:24]([O:26][CH3:27])=[O:25])[N:19]=3)=[CH:9][CH:8]=1.O=S1(=O)CCN(C[C:46]([N:48]([C:50]2C=CC(N/C(/C3C=CC=CC=3)=C3\C(=O)NC4C\3=CC=C(C(OC)=O)N=4)=C[CH:51]=2)[CH3:49])=[O:47])CC1.CN(C)CC(N(C1C=CC(N/C(/C2C=CC=CC=2)=C2\C(=O)NC3C\2=CC=C(C(OC)=O)N=3)=CC=1)C)=O.CN(CCN1CCN(C)CC1)C1C=CC(N/C(/C2C=CC=CC=2)=C2\C(=O)NC3C\2=CC=C(C(OC)=O)N=3)=CC=1.C(N(C)C(=O)CN(C)C1C=CC(N/C(/C2C=CC=CC=2)=C2\C(=O)NC3C=C(C(OC)=O)N=CC\2=3)=CC=1)C.CN(C)C(=O)CCN(C)C1C=CC(N/C(/C2C=CC=CC=2)=C2\C(=O)NC3C=C(C(OC)=O)N=CC\2=3)=CC=1.O=S1(=O)CCN(CC(N(C2C=CC(N/C(/C3C=CC=CC=3)=C3\C(=O)NC4C=C(C(OC)=O)N=CC\3=4)=CC=2)C)=O)CC1.CN(C)CC(N(C1C=CC(N/C(/C2C=CC=CC=2)=C2\C(=O)NC3C=C(C(OC)=O)N=CC\2=3)=CC=1)C)=O.CN(CCN1CCN(C)CC1)C1C=CC(N/C(/C2C=CC=CC=2)=C2\C(=O)NC3C=C(C(OC)=O)N=CC\2=3)=CC=1.C(N(C)C(=O)CN(C)C1C=CC(N/C(/C2C=CC=CC=2)=C2\C(=O)NC3C\2=NC=C(C(OC)=O)C=3)=CC=1)C.CN(C)C(=O)CCN(C)C1C=CC(N/C(/C2C=CC=CC=2)=C2\C(=O)NC3C\2=NC=C(C(OC)=O)C=3)=CC=1.O=S1(=O)CCN(CC(N(C2C=CC(N/C(/C3C=CC=CC=3)=C3\C(=O)NC4C\3=NC=C(C(OC)=O)C=4)=CC=2)C)=O)CC1.CN(C)CC(N(C1C=CC(N/C(/C2C=CC=CC=2)=C2\C(=O)NC3C\2=NC=C(C(OC)=O)C=3)=CC=1)C)=O.CN(CCN1CCN(C)CC1)C1C=CC(N/C(/C2C=CC=CC=2)=C2\C(=O)NC3C\2=NC=C(C(OC)=O)C=3)=CC=1>>[CH2:50]([N:48]([CH3:49])[C:46](=[O:47])[CH2:5][N:6]([CH3:35])[C:7]1[CH:12]=[CH:11][C:10]([NH:13]/[C:14](/[C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)=[C:15]2\[C:16](=[O:28])[NH:17][C:18]3[C:23]\2=[CH:22][CH:21]=[C:20]([C:24]([O:26][CH3:27])=[O:25])[N:19]=3)=[CH:9][CH:8]=1)[CH3:51]

Participants

Reactant 14

HCID 178464473HCID 178464473, compound

HCID 178464474HCID 178464474, compound

HCID 178496941HCID 178496941, compound

HCID 178496942HCID 178496942, compound

HCID 178496944HCID 178496944, compound

HCID 178496945HCID 178496945, compound

HCID 178497290HCID 178497290, compound

HCID 178497291HCID 178497291, compound

HCID 178497293HCID 178497293, compound

HCID 178497294HCID 178497294, compound

HCID 178498720HCID 178498720, compound

HCID 178498721HCID 178498721, compound

HCID 178498723HCID 178498723, compound

HCID 178498724HCID 178498724, compound

Product 1

HCID 178464475HCID 178464475, compound

Procedure

(Z)-methyl 3-(((4-((3-(dimethylamino)-3-oxopropyl)(methyl)amino)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-6-carboxylate; (Z)-methyl 3-(((4-(2-(1,1-dioxidothiomorpholino)-N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-6-carboxylate; (Z)-methyl 3-(((4-(2-(dimethylamino)-N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-6-carboxylate; (Z)-methyl 3-(((4-(methyl(2-(4-methylpiperazin-1-yl)ethyl)amino)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-6-carboxylate; (Z)-methyl 3-(((4-((2-(ethyl(methyl)amino)-2-oxoethyl)(methyl)amino)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine-6-carboxylate; (Z)-methyl 3-(((4-((3-(dimethylamino)-3-oxopropyl)(methyl)amino)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine-6-carboxylate; (Z)-methyl 3-(((4-(2-(1,1-dioxidothiomorpholino)-N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine-6-carboxylate; (Z)-methyl 3-(((4-(2-(dimethylamino)-N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine-6-carboxylate; (Z)-methyl 3-(((4-(methyl(2-(4-methylpiperazin-1-yl)ethyl)amino)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine-6-carboxylate; (Z)-methyl 3-(((4-((2-(ethyl(methyl)amino)-2-oxoethyl)(methyl)amino)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carboxylate; (Z)-methyl 3-(((4-((3-(dimethylamino)-3-oxopropyl)(methyl)amino)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carboxylate; (Z)-methyl 3-(((4-(2-(1,1-dioxidothiomorpholino)-N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carboxylate; (Z)-methyl 3-(((4-(2-(dimethylamino)-N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carboxylate; and (Z)-methyl 3-(((4-(methyl(2-(4-methylpiperazin-1-yl)ethyl)amino)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-6-carboxylate.

Sources & evidence

ORD record: ord-66b0c89776334284ac44ac96a3af83ea
Source dataset: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09040555B2

Reaction notes

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