Acetic Acid → HCID 117853300, compound

HRID 57781Notes

Reaction equation

HRID 57781 reaction equation
[CH3:1][C:2]1[C:10]2[C:9]([O:11][CH2:12][C:13]3[O:17][N:16]=[C:15]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[CH:14]=3)=[N:8][CH:7]=[N:6][C:5]=2[S:4][CH:3]=1.ClCCl.[C:27]([OH:30])(=[O:29])[CH3:28]>>[C:27]([OH:30])(=[O:29])[CH3:28].[CH3:1][C:2]1[C:10]2[C:9]([O:11][CH2:12][C:13]3[O:17][N:16]=[C:15]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[CH:14]=3)=[N:8][CH:7]=[N:6][C:5]=2[S:4][CH:3]=1

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 6344DichloromethaneHCID 734426745-Methyl-4-((3-phenyl-isoxazol-5-yl)-methoxy-)-thieno[2,3-d]pyrimidine

Product 1

HCID 117853300HCID 117853300, compoundYield 58%

Procedure

0.5 mmol of 5-methyl-4-((3-phenyl-isoxazol-5-yl)-methoxy-)-thieno[2,3-d]pyrimidine was added into a 50 ml single-necked round-bottom flask containing 10 ml of dry dichloromethane. 2 ml of acetic acid was added under stirring, and the mixture was stirred for 1-2 hours at 30-40. The mixture was cooled down, crystallized, filtered and dried under vacuum to afford 5-methyl-4-((3-phenyl-isoxazol-5-yl)-methoxy-)-thieno[2,3-d]pyrimidine acetate as a colorless solid in 58% yield.

Workup

  1. stirringthe mixture was stirred for 1-2 hours at 30-40
  2. temperatureThe mixture was cooled down
  3. customcrystallized
  4. filtrationfiltered
  5. customdried under vacuum

Sources & evidence

ORD record
ord-d9c2c71abb9045cc80015f3e8759c6b9
Source dataset
uspto-grants-2016_09
Patent number
US09434741B2

Reaction notes

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