HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Cyclopropyl-2-hydroxyacetonitrile → {5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl}(cyclopropyl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Cyclopropyl-2-hydroxyacetonitrile | HCID 11389359 | — |
| Reactant | (2R,6S)-4-(6-((tert-butyldiphenylsilyloxy)methyl)-2,3-difluorophenyl)-2,6-dimethylmorpholine | HCID 67357593 | — |
| Product | {5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl}(cyclopropyl)methanol | HCID 87368879 | — |
Reaction Steps
Starting material: (2R,6S)-4-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,3-difluorophenyl]-2,6-dimethylmorpholine (Intermediate 3) and cylopropyl carboxaldehyde.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09040528B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-2dd4682bc4714b8499e8cf7b32e711a8 |
| Source note | uspto-grants-2015_05 |