反应详情

To a stirred solution of (6-((2R,6S)-2,6-dimethylmorpholino)-7-fluoro-3-methylbenzo[d]isoxazol-5-yl)methanol (Intermediate 33, 0.65 g, 2.21 mmol) in CH2Cl2 (30 ml) was added MnO2 (3.84 g, 44.17 mmol). After stirring for 3 days at room temperature MnO2 was filtered and washed with CH2Cl2. The filtrate was concentrated and dried to give the title compound (0.547 g, 85%).

1. filtrationwas filtered
2. washwashed with CH2Cl2
3. concentrationThe filtrate was concentrated
4. customdried