2-Fluoro-4-formylbenzonitrile → HCID 67357725, compound

HRID 577853Notes

Reaction equation

HRID 577853 reaction equation
[Si:1]([O:18][CH2:19][C:20]1[C:25]([N:26]2[CH2:31][C@H:30]([CH3:32])[O:29][C@H:28]([CH3:33])[CH2:27]2)=[C:24]([Cl:34])[C:23]([F:35])=[CH:22][N:21]=1)([C:14]([CH3:17])([CH3:16])[CH3:15])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:36][C:37]1[CH:44]=[C:43]([CH:45]=[O:46])[CH:42]=[CH:41][C:38]=1[C:39]#[N:40]>>[Si:1]([O:18][CH2:19][C:20]1[N:21]=[C:22]([CH:45]([OH:46])[C:43]2[CH:42]=[CH:41][C:38]([C:39]#[N:40])=[C:37]([F:36])[CH:44]=2)[C:23]([F:35])=[C:24]([Cl:34])[C:25]=1[N:26]1[CH2:31][C@H:30]([CH3:32])[O:29][C@H:28]([CH3:33])[CH2:27]1)([C:14]([CH3:17])([CH3:15])[CH3:16])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 112173392-Fluoro-4-formylbenzonitrileHCID 67319975(2R,6S)-4-(2-((tert-Butyldiphenylsilyloxy)methyl)-4-chloro-5-fluoropyridin-3-yl)-2,6-dimethylmorpholine2×

Product 1

HCID 67357725HCID 67357725, compound

Procedure

Starting materials: (2R,6S)-4-(2-((tert-butyldiphenylsilyloxy)methyl)-4-chloro-5-fluoropyridin-3-yl)-2,6-dimethylmorpholine (Intermediate 45) and 2-fluoro-4-formylbenzonitrile.

Sources & evidence

ORD record
ord-aa8a4e7247524c94a9aa624e5d1dfc9e
Source dataset
uspto-grants-2015_05
Patent number
US09040528B2

Reaction notes

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