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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 577876Generated: October 30, 2026

2-fluoro-N-methoxy-N-methylbenzamide → (5-((tert-butyldiphenylsilyloxy)methyl)-4-((2R,6S)-2,6-dimethylmorpholino)-2,3-difluorophenyl)(2-fluorophenyl)methanone

https://huagongshe.com/reaction/577876

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-fluoro-N-methoxy-N-methylbenzamideHCID 18357556—
Reactant(2R,6S)-4-(6-((tert-butyldiphenylsilyloxy)methyl)-2,3-difluorophenyl)-2,6-dimethylmorpholineHCID 67357593—
Product(5-((tert-butyldiphenylsilyloxy)methyl)-4-((2R,6S)-2,6-dimethylmorpholino)-2,3-difluorophenyl)(2-fluorophenyl)methanoneHCID 86658074—

Reaction Steps

Starting materials: (2R,6S)-4-(6-((tert-butyldiphenylsilyloxy)methyl)-2,3-difluorophenyl)-2,6-dimethylmorpholine (Intermediate 3) and 2-fluoro-N-methoxy-N-methylbenzamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09040528B2
Source datasetuspto-grants-2015_05
ORD IDord-85e4e0b9cb6248518b2d9d01ef1b1ecf
Source noteuspto-grants-2015_05