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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 577877Generated: October 26, 2026

N-methoxy-N-methyloxane-4-carboxamide → (5-((tert-butyldiphenylsilyloxy)methyl)-4-((2R,6S)-2,6-dimethylmorpholino)-2,3-difluorophenyl)(tetrahydro-2H-pyran-4-yl)methanone

https://huagongshe.com/reaction/577877

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-methoxy-N-methyloxane-4-carboxamideHCID 23144693—
Reactant(2R,6S)-4-(6-((tert-butyldiphenylsilyloxy)methyl)-2,3-difluorophenyl)-2,6-dimethylmorpholineHCID 67357593—
Product(5-((tert-butyldiphenylsilyloxy)methyl)-4-((2R,6S)-2,6-dimethylmorpholino)-2,3-difluorophenyl)(tetrahydro-2H-pyran-4-yl)methanoneHCID 86658075—

Reaction Steps

Starting materials: (2R,6S)-4-(6-((tert-butyldiphenylsilyloxy)methyl)-2,3-difluorophenyl)-2,6-dimethylmorpholine (Intermediate 3) and N-methoxy-N-methyltetrahydro-2H-pyran-4-carboxamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09040528B2
Source datasetuspto-grants-2015_05
ORD IDord-b4d8ed803f874e7b9d19bafba1d3772b
Source noteuspto-grants-2015_05