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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 577878Generated: October 30, 2026

2-Chloro-N-methoxy-N-methylacetamide → 1-(5-((tert-butyldiphenylsilyloxy)methyl)-4-((2R,6S)-2,6-dimethylmorpholino)-2,3-difluorophenyl)-2-chloroethanone

https://huagongshe.com/reaction/577878

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-N-methoxy-N-methylacetamideHCID 2734716—
Reactant(2R,6S)-4-(6-((tert-butyldiphenylsilyloxy)methyl)-2,3-difluorophenyl)-2,6-dimethylmorpholineHCID 67357593—
Product1-(5-((tert-butyldiphenylsilyloxy)methyl)-4-((2R,6S)-2,6-dimethylmorpholino)-2,3-difluorophenyl)-2-chloroethanoneHCID 86658076—

Reaction Steps

Starting materials (2R,6S)-4-(6-((tert-butyldiphenylsilyloxy)methyl)-2,3-difluorophenyl)-2,6-dimethylmorpholine (Intermediate 3) and 2-chloro-N-methoxy-N-methylacetamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09040528B2
Source datasetuspto-grants-2015_05
ORD IDord-b1b51e0d84e74c8a838299e01a4f17fc
Source noteuspto-grants-2015_05