HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Difluoro-N-methoxy-N-methylacetamide → 1-(5-((tert-butyldiphenylsilyloxy)methyl)-4-((2R,6S)-2,6-dimethylmorpholino)-2,3-difluorophenyl)-2,2-difluoroethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Difluoro-N-methoxy-N-methylacetamide | HCID 19023731 | — |
| Reactant | (2R,6S)-4-(6-((tert-butyldiphenylsilyloxy)methyl)-2,3-difluorophenyl)-2,6-dimethylmorpholine | HCID 67357593 | — |
| Product | 1-(5-((tert-butyldiphenylsilyloxy)methyl)-4-((2R,6S)-2,6-dimethylmorpholino)-2,3-difluorophenyl)-2,2-difluoroethanone | HCID 86658078 | — |
Reaction Steps
Starting materials: (2R,6S)-4-(6-((tert-butyldiphenylsilyloxy)methyl)-2,3-difluorophenyl)-2,6-dimethylmorpholine (Intermediate 3) and 2,2-difluoro-N-methoxy-N-methylacetamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09040528B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-8a9935d7b11843ff98f8ec833a84e0c1 |
| Source note | uspto-grants-2015_05 |