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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 577914Generated: October 30, 2026

Ethanamine, N-methyl-, hydrochloride (1:1) → 5-((tert-butyldiphenylsilyloxy)methyl)-6-((2R,6S)-2,6-dimethylmorpholino)-N-ethyl-7-fluoro-N-methylbenzo[d]isoxazole-3-carboxamide

https://huagongshe.com/reaction/577914

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthanamine, N-methyl-, hydrochloride (1:1)HCID 522048—
Reactantethyl 5-((tert-butyldiphenylsilyloxy)methyl)-6-((2R,6S)-2,6-dimethylmorpholino)-7-fluorobenzo[d]isoxazole-3-carboxylateHCID 67357675—
Product5-((tert-butyldiphenylsilyloxy)methyl)-6-((2R,6S)-2,6-dimethylmorpholino)-N-ethyl-7-fluoro-N-methylbenzo[d]isoxazole-3-carboxamideHCID 67358128—

Reaction Steps

Starting materials: Ethyl 5-((tert-butyldiphenylsilyloxy)methyl)-6-((2R,6S)-2,6-dimethylmorpholino)-7-fluorobenzo[d]isoxazole-3-carboxylate (Intermediate 204) and N-methylethanamine hydrochloride

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09040528B2
Source datasetuspto-grants-2015_05
ORD IDord-344ab6f5473c4a4b9c6986332e7eaa66
Source noteuspto-grants-2015_05