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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 577929Generated: October 30, 2026

3,3-Difluoroazetidine hydrochloride → (3,3-Difluoroazetidin-1-yl)(5-(dimethoxymethyl)-6,7-difluorobenzo[d]isoxazol-3-yl)methanone

https://huagongshe.com/reaction/577929

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,3-Difluoroazetidine hydrochlorideHCID 2758247—
ReactantEthyl 5-(dimethoxymethyl)-6,7-difluorobenzo[d]isoxazole-3-carboxylateHCID 67360293—
Product(3,3-Difluoroazetidin-1-yl)(5-(dimethoxymethyl)-6,7-difluorobenzo[d]isoxazol-3-yl)methanoneHCID 67358946—

Reaction Steps

Starting materials: ethyl 5-(dimethoxymethyl)-6,7-difluorobenzo[d]isoxazole-3-carboxylate (Intermediate 206) and 3,3-difluoroazetidine hydrochloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09040528B2
Source datasetuspto-grants-2015_05
ORD IDord-df890b674ab447e789e3946e76a1af10
Source noteuspto-grants-2015_05