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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 577935Generated: October 31, 2026

Neopentylamine → 5-((tert-Butyldiphenylsilyloxy)methyl)-7-chloro-6-((2R,6S)-2,6-dimethylmorpholino)-N-neopentylisoxazolo[4,5-b]pyridine-3-carboxamide

https://huagongshe.com/reaction/577935

Reaction equation

Participants

RoleNameHCIDCharge
ReactantNeopentylamineHCID 79882—
ReactantEthyl 5-((tert-butyldiphenylsilyloxy)methyl)-7-chloro-6-((2R,6S)-2,6-dimethylmorpholino)isoxazolo[4,5-b]pyridine-3-carboxylateHCID 67356857—
Product5-((tert-Butyldiphenylsilyloxy)methyl)-7-chloro-6-((2R,6S)-2,6-dimethylmorpholino)-N-neopentylisoxazolo[4,5-b]pyridine-3-carboxamideHCID 67357043—

Reaction Steps

Starting material: ethyl 5-((tert-butyldiphenylsilyloxy)methyl)-7-chloro-6-((2R,6S)-2,6-dimethylmorpholino)isoxazolo[4,5-b]pyridine-3-carboxylate (Intermediate 211) and 2,2-dimethylpropan-1-amine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09040528B2
Source datasetuspto-grants-2015_05
ORD IDord-ce19bb5932d34444b7289cc547ed6a0d
Source noteuspto-grants-2015_05