Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 577948Generated: October 26, 2026

N-(azetidin-3-yl)acetamide → N-(1-(6-((2R,6S)-2,6-dimethylmorpholino)-7-fluoro-5-(hydroxymethyl)benzo[d]isoxazole-3-carbonyl)azetidin-3-yl)acetamide

https://huagongshe.com/reaction/577948

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(azetidin-3-yl)acetamideHCID 13401968—
Reactantethyl 5-((tert-butyldiphenylsilyloxy)methyl)-6-((2R,6S)-2,6-dimethylmorpholino)-7-fluorobenzo[d]isoxazole-3-carboxylateHCID 67357675—
ProductN-(1-(6-((2R,6S)-2,6-dimethylmorpholino)-7-fluoro-5-(hydroxymethyl)benzo[d]isoxazole-3-carbonyl)azetidin-3-yl)acetamideHCID 67358761—

Reaction Steps

Starting materials: ethyl 5-((tert-butyldiphenylsilyloxy)methyl)-6-((2R,6S)-2,6-dimethylmorpholino)-7-fluorobenzo[d]isoxazole-3-carboxylate (Intermediate 204) and N-(azetidin-3-yl)acetamide

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09040528B2
Source datasetuspto-grants-2015_05
ORD IDord-0df0c0fb59c240d29a6db720563f2a7e
Source noteuspto-grants-2015_05