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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 577949Generated: October 29, 2026

(1-Methylpyrazol-3-yl)methanamine → 6-((2R,6S)-2,6-dimethylmorpholino)-7-fluoro-5-(hydroxymethyl)-N-((1-methyl-1H-pyrazol-3-yl)methyl)benzo[d]isoxazole-3-carboxamide

https://huagongshe.com/reaction/577949

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(1-Methylpyrazol-3-yl)methanamineHCID 7019419—
Reactantethyl 5-((tert-butyldiphenylsilyloxy)methyl)-6-((2R,6S)-2,6-dimethylmorpholino)-7-fluorobenzo[d]isoxazole-3-carboxylateHCID 67357675—
Product6-((2R,6S)-2,6-dimethylmorpholino)-7-fluoro-5-(hydroxymethyl)-N-((1-methyl-1H-pyrazol-3-yl)methyl)benzo[d]isoxazole-3-carboxamideHCID 67357648—

Reaction Steps

Starting materials: ethyl 5-((tert-butyldiphenylsilyloxy)methyl)-6-((2R,6S)-2,6-dimethylmorpholino)-7-fluorobenzo[d]isoxazole-3-carboxylate (Intermediate 204) and (1-methyl-1H-pyrazol-3-yl)methanamine

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09040528B2
Source datasetuspto-grants-2015_05
ORD IDord-ef11c2dbbe5d46949e4694b99b19407c
Source noteuspto-grants-2015_05