HCID 67433731, compound → HCID 86658117, compound

HRID 577974Notes

Reaction equation

HRID 577974 reaction equation
[Cl:1][C:2]1[C:7]([N:8]2[CH2:13][C@H:12]([CH3:14])[O:11][C@H:10]([CH3:15])[CH2:9]2)=[C:6]([CH2:16][OH:17])[N:5]=[C:4]2[C:18]([C:21]([NH:23][CH3:24])=[O:22])=[N:19][O:20][C:3]=12>C(Cl)Cl>[Cl:1][C:2]1[C:7]([N:8]2[CH2:13][C@H:12]([CH3:14])[O:11][C@H:10]([CH3:15])[CH2:9]2)=[C:6]([CH:16]=[O:17])[N:5]=[C:4]2[C:18]([C:21]([NH:23][CH3:24])=[O:22])=[N:19][O:20][C:3]=12

Participants

3

Reactant 1

HCID 67433731HCID 67433731, compound2×

Product 1

HCID 86658117HCID 86658117, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Starting material: 7-chloro-6-((2R,6S)-2,6-dimethylmorpholino)-5-(hydroxymethyl)-N-methylisoxazolo[4,5-b]pyridine-3-carboxamide (Intermediate 293) in 20 ml CH2Cl2.

Sources & evidence

ORD record
ord-2d05230e2fa24acfaaf819f67bdc757b
Source dataset
uspto-grants-2015_05
Patent number
US09040528B2

Reaction notes

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