反应详情

A solution of 17 parts of methyl N-(2,3-dihydro-3-methyl-1H-inden-1-yl)glycine in 60 parts of formic acid and 20 parts of acetic acid anhydride is stirred overnight at room temperature. The reaction mixture is evaporated in vacuo and the residue is taken up in 1,1'-oxybisethane. The organic layer is washed with a sodium hydrogen carbonate solution and water dried, filtered and evaporated. The residue is crystallized from a mixture of 2,2'-oxybispropane and hexane. The product is filtered off and dried, yielding 15 parts (78.7%) of methyl N-(2,3-dihydro-3-methyl-1H-inden-1-yl)-N-formylglycine.

1. customThe reaction mixture is evaporated in vacuo
2. washThe organic layer is washed with a sodium hydrogen carbonate solution and water
3. customdried
4. filtrationfiltered
5. customevaporated
6. customThe residue is crystallized from a mixture of 2,2'-oxybispropane and hexane
7. filtrationThe product is filtered off
8. customdried