1-(2-Bromoethyl)-4-(trifluoromethyl)benzene → 2-Cyclopropyl-7-oxo-4-[2-(4-trifluoromethyl-phenyl)-ethyl]-4,7-dihydro-pyrazolo[1,5-a]-pyrimidine-6-carboxylic acid

HRID 57800Notes

Reaction equation

HRID 57800 reaction equation
C([O:3][C:4]([C:6]1[C:11](=[O:12])[N:10]2[N:13]=[C:14]([CH:16]3[CH2:18][CH2:17]3)[CH:15]=[C:9]2[N:8]([CH2:19][CH2:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][CH:22]=2)[CH:7]=1)=[O:5])C.BrCCC1C=CC(C(F)(F)F)=CC=1>>[CH:16]1([C:14]2[CH:15]=[C:9]3[N:8]([CH2:19][CH2:20][C:21]4[CH:22]=[CH:23][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:25][CH:26]=4)[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[C:11](=[O:12])[N:10]3[N:13]=2)[CH2:18][CH2:17]1

Participants

3

Reactant 2

HCID 149499411-(2-Bromoethyl)-4-(trifluoromethyl)benzeneHCID 867029412-Cyclopropyl-7-oxo-4-[2-(4-trifluoromethyl-phenyl)-ethyl]-4,7-dihydro-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid ethyl ester

Product 1

HCID 867029402-Cyclopropyl-7-oxo-4-[2-(4-trifluoromethyl-phenyl)-ethyl]-4,7-dihydro-pyrazolo[1,5-a]-pyrimidine-6-carboxylic acid

Procedure

The expected compound was obtained according to general procedure G using 2-cyclopropyl-7-oxo-4-[2-(4-trifluoromethyl-phenyl)-ethyl]-4,7-dihydro-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid ethyl ester. The starting material was obtained according to general procedure D using Key Intermediate II and 1-(2-bromo-ethyl)-4-trifluoromethyl-benzene. The expected compound was isolated as white powder.

Workup

  1. customThe starting material was obtained

Sources & evidence

ORD record
ord-8761368dafc442abb2d7d55f373f3d95
Source dataset
uspto-grants-2016_09
Patent number
US09434745B2

Reaction notes

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