HuagongsheHuagongshe Chemistry Print Report · For research reference only
Barbituric Acid → HCID 45381877, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Barbituric Acid | HCID 6211 | — |
| Reactant | HCID 87369354 | HCID 87369354 | — |
| Product | HCID 45381877 | HCID 45381877 | — |
Reaction Steps
Starting material: Barbituric acid and N-(2,2-difluoroethyl)-6-((2R,6S)-2,6-dimethylmorpholino)-7-fluoro-5-formylbenzo[d]isoxazole-3-carboxamide were reacted (Intermediate 467) using a method similar to the one described for the synthesis of Example 134. The product was purified by reverse phase HPLC using a gradient of CH3CN in water with 0.1% TFA.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09040528B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-38042097ddb54286978c5d638a1fe98f |
| Source note | uspto-grants-2015_05 |