Hydrochloric Acid → 2-(3,5-Dichloro-pyridin-4-yl-amino)-1-methyl-1H-benzimidazole-5-carboxylic acid

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Reaction Steps

A mixture of the product obtained at (547a) (240 mg, 0.68 mmol) in 10 mL methanol and 5 mL 4M NaOH (aq) was stirred at ambient temperature for 2 h, the another 5 mL 4M NaOH (aq) were added and the mixture stirred for 16 h at ambient temperature. The mixture was acidified by addition of 4M HCl (aq), the precipitate was filtered, washed with water and dried at 70° C.

Provenance & Evidence