Ammonia → HCID 67026134, compound

HRID 578085Notes

Reaction equation

HRID 578085 reaction equation
[OH:1][N:2]=[C:3]([NH2:10])[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[F:11][C:12]([F:26])([F:25])[S:13]([C:16]1[CH:17]=[C:18]([CH:22]=[CH:23][CH:24]=1)[C:19](Cl)=O)(=[O:15])=[O:14].N>>[N:6]1[CH:7]=[CH:8][CH:9]=[C:4]([C:3]2[N:10]=[C:19]([C:18]3[CH:22]=[CH:23][CH:24]=[C:16]([S:13]([C:12]([F:26])([F:11])[F:25])(=[O:14])=[O:15])[CH:17]=3)[O:1][N:2]=2)[CH:5]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 308113N-HydroxynicotinimidamideHCID 59819913HCID 59819913, compound

Product 1

HCID 67026134HCID 67026134, compound

Procedure

The title compound was prepared according to the procedure of Example 1 using N′-hydroxynicotinimidamide (Aldrich) and the compound of Example 6B. 1H NMR (300 MHz, DMSO-d6) δ 7.73 (dd, J=4, 5.0 Hz, 1H), 7.85 (t, J=8 Hz, 1H), 8.13 (m, 1H), 8.43 (m, 1H) 8.5 (m, 1H), 8.6 (m, 1H), 8.92 (m, 1H), 9.37 (m, 1H) ppm; MS (DCI/NH3) m/z 356 (M+H)+.

Sources & evidence

ORD record
ord-4eca3be02f6d4cab94493bdab78c4346
Source dataset
uspto-grants-2015_05
Patent number
US09040568B2

Reaction notes

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