HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(3,5-Difluorophenyl)-3-(pyridin-3-yl)-1,2,4-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3,5-Difluorobenzoic acid | HCID 101265 | — |
| Reactant | N-Hydroxynicotinimidamide | HCID 308113 | — |
| Product | 5-(3,5-Difluorophenyl)-3-(pyridin-3-yl)-1,2,4-oxadiazole | HCID 67026071 | — |
Reaction Steps
The title compound was prepared according to the procedure of Example 8 using N′-hydroxynicotinimidamide (Aldrich) and 3,5-difluorobenzoic acid (Aldrich). 1H NMR (300 MHz, CD3OD) δ 7.37 (tt, J=9.0, 2.3 Hz, 1H), 7.65 (ddd, J=7.9, 5.0, 1.0 Hz, 1H), 7.82-7.91 (m, 2H), 8.56 (dt, J=7.9, 2.0 Hz, 1H), 8.75 (dd, J=4.8, 1.6 Hz, 1H), 9.30 (dd, J=2.0, 0.8 Hz, 1H) ppm; MS (DCI/NH3) m/z 260 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09040568B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-fc2143c9b4b746b592ea9a1ff026b384 |
| Source note | uspto-grants-2015_05 |