Ammonia → HCID 67026267, compound

HRID 578100Notes

Reaction equation

[OH:1][N:2]=[C:3]([NH2:10])[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[F:11][C:12]1[CH:20]=[CH:19][C:15]([C:16](O)=O)=[CH:14][C:13]=1[OH:21].N>>[F:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]2[O:1][N:2]=[C:3]([C:4]3[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=3)[N:10]=2)=[CH:14][C:13]=1[OH:21]

Participants

Reactant 3

HCID 222Ammonia

HCID 308113N-Hydroxynicotinimidamide

HCID 5936354-Fluoro-3-hydroxybenzoic acid

Product 1

HCID 67026267HCID 67026267, compound

Procedure

The title compound was prepared according to the procedure of Example 8 using N′-hydroxynicotinimidamide (Aldrich) and 4-fluoro-3-hydroxybenzoic acid (Aldrich). 1H NMR (300 MHz, DMSO-d6) δ 7.45 (dd, J=11.1, 8.7 Hz, 1H), 7.62-7.71 (m, 2H), 7.78 (dd, J=8.3, 2.0 Hz, 1H), 8.43 (dt, J=7.9, 1.8 Hz, 1H), 8.82 (dd, J=5.0, 1.8 Hz, 1H), 9.24 (d, J=2.0 Hz, 1H) ppm; MS (DCI/NH3) m/z 258 (M+H)+.

Sources & evidence

ORD record: ord-17ba5769809f43669c1d47d1df6df5ee
Source dataset: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09040568B2

Reaction notes

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