Ammonia → HCID 136360178, compound

HRID 578101Notes

Reaction equation

HRID 578101 reaction equation
[OH:1][N:2]=[C:3]([NH2:10])[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[F:11][C:12]1[CH:13]=[C:14]([CH:18]=[CH:19][C:20]=1[OH:21])[C:15](O)=O.N>>[F:11][C:12]1[CH:13]=[C:14]([C:15]2[O:1][N:2]=[C:3]([C:4]3[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=3)[N:10]=2)[CH:18]=[CH:19][C:20]=1[OH:21]

Participants

4

Reactant 3

HCID 222AmmoniaHCID 1604563-Fluoro-4-hydroxybenzoic acidHCID 308113N-Hydroxynicotinimidamide

Product 1

HCID 136360178HCID 136360178, compound

Procedure

The title compound was prepared according to the procedure of Example 8 using N′-hydroxynicotinimidamide (Aldrich) and 3-fluoro-4-hydroxybenzoic acid (Aldrich). 1H NMR (300 MHz, CD3OD) δ 7.09 (t, J=8.7 Hz, 1H), 7.63 (ddd, J=7.9, 5.2, 0.8 Hz, 1H), 7.86-7.93 (m, 2H), 8.53 (dt, J=7.9, 2.0 Hz, 1H), 8.72 (dd, J=4.8, 1.6 Hz, 1H), 9.27 (dd, J=2.4, 0.8 Hz, 1H) ppm; MS (DCI/NH3) m/z 258 (M+H)+.

Sources & evidence

ORD record
ord-f6f4034d6c5445498825a207512d2426
Source dataset
uspto-grants-2015_05
Patent number
US09040568B2

Reaction notes

Loading…