HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-Nitro-5-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3-Hydroxy-4-nitrobenzoic acid | HCID 69265 | — |
| Reactant | N-Hydroxynicotinimidamide | HCID 308113 | — |
| Product | 2-Nitro-5-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)phenol | HCID 67026095 | — |
Reaction Steps
The title compound was prepared according to the procedure of Example 8 using N′-hydroxynicotinimidamide (Aldrich) and 3-hydroxy-4-nitrobenzoic acid (Maybridge). 1H NMR (300 MHz, DMSO-d6) δ 6.51 (d, J=9.1 Hz, 1H), 6.92-7.31 (s (broad), 1H), 7.61 (ddd, J=7.9, 4.8, 0.8 Hz, 1H), 7.68 (dd, J=9.1, 2.4 Hz, 1H), 8.40 (dt, J=7.9, 2.0 Hz, 1H), 8.53 (d, J=2.4 Hz, 1H), 8.77 (dd, J=4.8, 1.6 Hz, 1H), 9.20 (d, J=1.6 Hz, 1H) ppm; MS (DCI/NH3) m/z 285 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09040568B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-ff8486e1d7e34c3aa6a7c462154442db |
| Source note | uspto-grants-2015_05 |