Ammonia → HCID 86621257, compound

HRID 578106Notes

Reaction equation

HRID 578106 reaction equation
[OH:1][N:2]=[C:3]([NH2:10])[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[F:11][C:12]([F:25])([F:24])[C:13]([C:15]1[CH:23]=[CH:22][C:18]([C:19]([OH:21])=O)=[CH:17][CH:16]=1)=[O:14].N>>[F:11][C:12]([F:25])([F:24])[C:13]([OH:1])=[O:14].[F:24][C:12]([F:11])([F:25])[C:13]([C:15]1[CH:16]=[CH:17][C:18]([C:19]2[O:21][N:10]=[C:3]([C:4]3[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=3)[N:2]=2)=[CH:22][CH:23]=1)=[O:14]

Participants

4

Reactant 3

HCID 222AmmoniaHCID 1435794-(Trifluoroacetyl)benzoic acidHCID 308113N-Hydroxynicotinimidamide

Product 1

HCID 86621257HCID 86621257, compound

Procedure

The title compound was prepared according to the procedure of Example 8 using N′-hydroxynicotinimidamide (Aldrich) and 4-(2,2,2-trifluoroacetyl)benzoic acid (Aldrich). 1H NMR (300 MHz, CD3OD) δ 7.81 (ddd, J=7.9, 5.2, 0.8 Hz, 1H), 7.96 (d, J=8.3 Hz, 2H), 8.28 (d, J=8.7 Hz, 2H), 8.76 (dt, J=8.2, 1.8 Hz, 1H), 8.82 (dd, J=5.2, 1.6 Hz, 1H), 9.38 (d, J=1.6 Hz, 1H) ppm; MS (DCI/NH3) m/z 320 (M+H)+.

Sources & evidence

ORD record
ord-2ac777e88864409f9f78f0fd3fd5c8c0
Source dataset
uspto-grants-2015_05
Patent number
US09040568B2

Reaction notes

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