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Ammonia → 3-(2,3-Difluorophenyl)-5-(pyridin-3-yl)-1,2,4-oxadiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 3-Pyridinecarbonyl chloride, hydrochloride (1:1) | HCID 88438 | — |
| 反応物 | 2,3-difluoro-N'-hydroxybenzenecarboximidamide | HCID 3278378 | — |
| 生成物 | 3-(2,3-Difluorophenyl)-5-(pyridin-3-yl)-1,2,4-oxadiazole | HCID 67026030 | — |
反応手順
The title compound was prepared according to the procedure of Example 1 using 2,3-difluoro-N′-hydroxybenzimidamide (Tyger Scientific) and nicotinoyl chloride hydrochloride (Aldrich). 1H NMR (300 MHz, DMSO-d6) δ 7.42-7.61 (m, 1H), 7.67-7.85 (m, 2H), 7.91-8.04 (m, 1H), 8.57 (dt, J=8.1, 1.9 Hz, 1H), 8.92 (dd, J=4.8, 1.6 Hz, 1H), 9.36 (dd, J=2.4, 0.8 Hz, 1H) ppm; MS (DCI/NH3) m/z 260 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09040568B2 |
| 出典データセット | uspto-grants-2015_05 |
| ORD ID | ord-12f2337d1de049619072edb68ef25e51 |
| 出典メモ | uspto-grants-2015_05 |