HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-(3,4-Difluorophenyl)-5-(pyridin-3-yl)-1,2,4-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3-Pyridinecarbonyl chloride, hydrochloride (1:1) | HCID 88438 | — |
| Reactant | 3,4-difluoro-N'-hydroxybenzenecarboximidamide | HCID 4094371 | — |
| Product | 3-(3,4-Difluorophenyl)-5-(pyridin-3-yl)-1,2,4-oxadiazole | HCID 67026032 | — |
Reaction Steps
The title compound was prepared according to the procedure of Example 1 using 3,4-difluoro-N′-hydroxybenzimidamide (Tyger Scientific) and nicotinoyl chloride hydrochloride (Aldrich). 1H NMR (300 MHz, DMSO-d6) δ 7.74 (dd, J=7.5, 4.4 Hz, 1H), 8.60 (dt, J=7.8, 2.1 Hz, 1H), 8.93 (dd, J=4.8, 1.6 Hz, 1H), 9.38 (dd, J=2.2, 1.0 Hz, 1H), 9.44-9.48 (m, 3H) ppm; MS (DCI/NH3) m/z 260 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09040568B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-4e8cc29a443341c29aa252c7d963d502 |
| Source note | uspto-grants-2015_05 |