Ammonia → HCID 67026265, compound

HRID 578114Notes

Reaction equation

HRID 578114 reaction equation
[OH:1][N:2]=[C:3]([NH2:10])[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[F:11][C:12]1[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[C:13]=1[C:14](O)=O.N>>[F:11][C:12]1[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[C:13]=1[C:14]1[O:1][N:2]=[C:3]([C:4]2[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=2)[N:10]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 97962,6-Difluorobenzoic acidHCID 308113N-Hydroxynicotinimidamide

Product 1

HCID 67026265HCID 67026265, compound

Procedure

The title compound was prepared according to the procedure of Example 8 using N′-hydroxynicotinimidamide (Aldrich) and 2,6-difluorobenzoic acid (Aldrich). 1H NMR (300 MHz, CD3OD) δ 7.29 (t, J=8.6 Hz, 2H), 7.65 (ddd, J=8.0, 4.9, 1.0 Hz, 1H), 7.77 (tt, J=8.6, 6.1 Hz, 1H), 8.57 (ddd, J=8.3, 1.9, 1.7 Hz, 1H), 8.75 (dd, J=4.7, 1.7 Hz, 1H), 9.30 (dd, J=2.2, 0.8 Hz, 1H) ppm; MS (DCI/NH3) m/z 260 (M+H)+.

Sources & evidence

ORD record
ord-d23505a67afd4b6c9ea61d17fc5adfed
Source dataset
uspto-grants-2015_05
Patent number
US09040568B2

Reaction notes

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