Ammonia → HCID 67026129, compound

HRID 578124Notes

Reaction equation

HRID 578124 reaction equation
[OH:1][N:2]=[C:3]([NH2:10])[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[C:11]([O:15][C:16]([C:18]1[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=1)[C:21](O)=O)=[O:17])([CH3:14])([CH3:13])[CH3:12].N>>[N:6]1[CH:7]=[CH:8][CH:9]=[C:4]([C:3]2[N:10]=[C:21]([C:20]3[CH:19]=[C:18]([CH:26]=[CH:25][CH:24]=3)[C:16]([O:15][C:11]([CH3:14])([CH3:12])[CH3:13])=[O:17])[O:1][N:2]=2)[CH:5]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 308113N-HydroxynicotinimidamideHCID 27609513-(tert-Butoxycarbonyl)benzoic acid

Product 1

HCID 67026129HCID 67026129, compound

Procedure

N′-Hydroxynicotinimidamide (274 mg, 2.00 mmol) was coupled with 3-(tert-butoxycarbonyl)benzoic acid (Aldrich) according to the procedure described in Example 8. 1H NMR (300 MHz, CD3OD) δ 1.65 (s, 9H), 7.65 (ddd, J=7.9, 4.8, 0.8 Hz, 1H), 7.71-7.77 (m, 1H), 8.26 (ddd, J=7.7, 1.8, 1.6 Hz, 1H), 8.42-8.46 (m, 1H), 8.57 (dt, J=7.9, 2.0 Hz, 1H), 8.73-8.78 (m, 2H), 9.31 (dd, J=2.2, 1.0 Hz, 1H) ppm; MS (DCI/NH3) m/z 324 (M+H)+.

Sources & evidence

ORD record
ord-a10d2ca3d656416995b4370f68c2b6cb
Source dataset
uspto-grants-2015_05
Patent number
US09040568B2

Reaction notes

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