Ammonia → HCID 30028850, compound

HRID 578129Notes

Reaction equation

HRID 578129 reaction equation
[OH:1][N:2]=[C:3]([NH2:10])[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[Cl:11][C:12]1[CH:20]=[CH:19][C:15]([C:16](Cl)=O)=[CH:14][N:13]=1.N>>[Cl:11][C:12]1[N:13]=[CH:14][C:15]([C:16]2[O:1][N:2]=[C:3]([C:4]3[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=3)[N:10]=2)=[CH:19][CH:20]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 308113N-HydroxynicotinimidamideHCID 27821656-Chloronicotinoyl Chloride

Product 1

HCID 30028850HCID 30028850, compound

Procedure

The title compound was prepared according to the procedure of Example 1 using N′-hydroxynicotinimidamide (Tyger) and 6-chloronicotinoyl chloride (Aldrich). 1H NMR (300 MHz, CDCl3) δ 7.48 (dd, J=7.6, 5.3 Hz, 1H), 7.57 (d, J=8.5 Hz, 1H), 8.40-8.48 (m, 2H), 8.80 (dd, J=4.7, 1.7 Hz, 1H), 9.24 (d, J=2.4 Hz, 1H), 9.40 (d, J=2.4 Hz, 1H) ppm; MS (DCI/NH3) m/z 259 (M+H)+, 261 (M+H)+.

Sources & evidence

ORD record
ord-6b50d9adecf146d6824dcad14d92564a
Source dataset
uspto-grants-2015_05
Patent number
US09040568B2

Reaction notes

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