HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → Tert-butyl 3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | N-Hydroxynicotinimidamide | HCID 308113 | — |
| Reactant | 3-(((tert-Butoxycarbonyl)amino)methyl)benzoic acid | HCID 2755929 | — |
| Product | Tert-butyl 3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzylcarbamate | HCID 67026201 | — |
Reaction Steps
The title compound was prepared according to the procedure of Example 8 using N′-hydroxynicotinimidamide (Aldrich) and 3-((tert-butoxycarbonylamino)methyl)benzoic acid (Fluka). 1H NMR (300 MHz, DMSO-d6) δ 1.42 (s, 9H), 4.27 (d, J=6.1 Hz, 2H), 7.51-7.72 (m, 4H), 8.01-8.17 (m, 2H), 8.45 (dt, J=8.1, 1.9 Hz, 1H), 8.82 (dd, J=5.1, 1.7 Hz, 1H), 9.26 (dd, J=2.2, 0.8 Hz, 1H) ppm; MS (DCI/NH3) m/z 353 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09040568B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-ac4f5d77dd1f45ec8733c022a62a080b |
| Source note | uspto-grants-2015_05 |