Ammonia → HCID 178420782, compound

HRID 578141Notes

Reaction equation

HRID 578141 reaction equation
[OH:1][N:2]=[C:3]([NH2:10])[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[NH:11]1[CH:15]=[CH:14][C:13]([C:16]2[CH:17]=[C:18]([CH:22]=[CH:23][CH:24]=2)[C:19](O)=O)=[N:12]1.N>>[NH:11]1[CH:15]=[CH:14][C:13]([C:16]2[CH:17]=[C:18]([C:19]3[O:1][N:2]=[C:3]([C:4]4[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=4)[N:10]=3)[CH:22]=[CH:23][CH:24]=2)=[N:12]1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 308113N-HydroxynicotinimidamideHCID 178524327HCID 178524327, compound

Product 1

HCID 178420782HCID 178420782, compound

Procedure

The title compound was prepared according to the procedure of Example 8 using N′-hydroxynicotinimidamide (Aldrich) and 3-(1H-pyrazol-3-yl)benzoic acid (Maybridge). 1H NMR (300 MHz, DMSO-d6) δ 6.91 (d, J=2.4 Hz, 1H), 7.62-7.69 (m, 1H), 7.72 (t, J=7.8 Hz, 1H), 7.79-7.92 (m, 1H), 7.82-7.88 (m, 1H), 8.10-8.20 (m, 3H), 8.49 (dt, J=8.2, 1.9, 1.7 Hz, 1H), 8.64 (s, 1H), 8.83 (dd, J=4.7, 1.7 Hz, 1H), 9.29 (dd, J=2.2, 0.8 Hz, 1H) ppm; MS (DCI/NH3) m/z 290 (M+H)+.

Sources & evidence

ORD record
ord-7ad1a1da3c1e42209f8f8163c9ef33b1
Source dataset
uspto-grants-2015_05
Patent number
US09040568B2

Reaction notes

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