HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(3,4-Difluorophenyl)-3-(pyridazin-4-yl)-1,2,4-oxadiazole → 5-(3,4-Difluorophenyl)-3-(pyridazin-4-yl)-1,2,4-oxadiazole hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(3,4-Difluorophenyl)-3-(pyridazin-4-yl)-1,2,4-oxadiazole | HCID 44511305 | — |
| Reactant | (R)-3-(Pyridin-3-yl)-5-(3-(pyrrolidin-2-yl)phenyl)-1,2,4-oxadiazole bis(hydrochloric acid) | HCID 67343123 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-(3,4-Difluorophenyl)-3-(pyridazin-4-yl)-1,2,4-oxadiazole hydrochloride | HCID 67026170 | — |
Reaction Steps
A solution of the product of Example 83E (140 mg, 0.54 mmol) in ethyl acetate (5.0 mL) was stirred with hydrochloric acid (Aldrich, 4 M in dioxane, 0.25 mL, 1.0 mmol) at ambient temperature for 10 hours. The white precipitates were collected by filtration and dried to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ 7.81 (dt, J=10.5, 8.5 Hz, 1H), 8.08-8.19 (m, 1H), 8.26-8.39 (m, 2H), 9.55 (dd, J=5.4, 1.4 Hz, 1H), 9.83 (dd, J=2.4, 1.4 Hz, 1H) ppm; MS (DCI/NH3) m/z 261 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09040568B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-b33812e55d57450ab053f12246ad8da1 |
| Source note | uspto-grants-2015_05 |