Ammonia → HCID 44544668, compound

HRID 578154Notes

Reaction equation

HRID 578154 reaction equation
[OH:1][N:2]=[C:3]([NH2:10])[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[N:11]1[CH:16]=[C:15]([C:17](O)=O)[CH:14]=[N:13][CH:12]=1.N>>[N:6]1[CH:7]=[CH:8][CH:9]=[C:4]([C:3]2[N:10]=[C:17]([C:15]3[CH:16]=[N:11][CH:12]=[N:13][CH:14]=3)[O:1][N:2]=2)[CH:5]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 78346Pyrimidine-5-carboxylic acidHCID 308113N-Hydroxynicotinimidamide

Product 1

HCID 44544668HCID 44544668, compound

Procedure

The titled compound was prepared according to the procedure of Method C using N′-hydroxynicotinimidamide (Tyger) and pyrimidine-5-carboxylic acid (Maybridge). 1H NMR (300 MHz, DMSO-d6) δ 7.68 (ddd, J=8.0, 4.9, 1.0 Hz, 1H), 8.48 (dt, J=7.7, 2.1 Hz, 1H), 8.84 (dd, J=4.7, 1.7 Hz, 1H), 9.29 (dd, J=2.4, 1.0 Hz, 1H), 9.51 (s, 1H), 9.56 (s, 2H) ppm; MS (DCI/NH3) m/z=226 (M+H)+, 243 (M+NH4)+.

Sources & evidence

ORD record
ord-a1b52e426da543ab9767617419a2a9f1
Source dataset
uspto-grants-2015_05
Patent number
US09040568B2

Reaction notes

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