HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-(3,5-Difluorophenyl)-3-(pyridazin-4-yl)-1,2,4-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3,5-Difluorobenzoyl chloride | HCID 145600 | — |
| Reactant | N-Hydroxy-4-pyridazinecarboximidamide | HCID 136140373 | — |
| Product | 5-(3,5-Difluorophenyl)-3-(pyridazin-4-yl)-1,2,4-oxadiazole | HCID 44544769 | — |
Reaction Steps
The titled compound was prepared according to the procedure of Method D using the product of Example 83D and 3,5-difluorobenzoyl chloride (Aldrich). 1H NMR (300 MHz, CD3OD) δ 7.40 (tt, J=8.9, 2.4 Hz, 1H), 7.85-7.94 (m, 2H), 8.39 (dd, J=5.4, 2.2 Hz, 1H), 9.46 (dd, J=5.4, 1.4 Hz, 1H), 9.87 (dd, J=2.2, 1.4 Hz, 1H) ppm; MS (DCI/NH3) m/z=261 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09040568B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-f05992f8acbb481395510bd5d07e7b37 |
| Source note | uspto-grants-2015_05 |