Ammonia → HCID 44544869, compound

HRID 578167Notes

Reaction equation

HRID 578167 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:10]([OH:12])=O)[CH:8]=2)[CH:3]=[CH:2]1.O[N:14]=[C:15]([NH2:22])[C:16]1[CH:21]=[CH:20][CH:19]=[N:18][CH:17]=1.N>>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:10]3[O:12][N:22]=[C:15]([C:16]4[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=4)[N:14]=3)[CH:8]=2)[CH:3]=[CH:2]1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 308113N-HydroxynicotinimidamideHCID 5952301H-indole-6-carboxylic acid

Product 1

HCID 44544869HCID 44544869, compound

Procedure

The title compound was prepared according to Method C using 1H-indole-6-carboxylic acid (Aldrich) and N′-hydroxynicotinimidamide (Tyger). 1H NMR (300 MHz, DMSO-d6) δ 6.62 (ddd, J=3.0, 1.9, 0.8 Hz, 1H), 7.62-7.71 (m, 2H), 7.76-7.89 (m, 2H), 8.27-8.33 (m, J=1.4 Hz, 1H), 8.46 (dt, J=8.2, 1.9, 1.7 Hz, 1H), 8.82 (dd, J=4.7, 1.7 Hz, 1H), 9.27 (dd, J=2.2, 0.8 Hz, 1H), 11.66 (s, 1H) ppm; MS (DCI/NH3) m/z 263 (M+H)+.

Sources & evidence

ORD record
ord-9507f7fac13845209de695b23ee5130c
Source dataset
uspto-grants-2015_05
Patent number
US09040568B2

Reaction notes

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