Ammonia → HCID 44544871, compound

HRID 578169Notes

Reaction equation

HRID 578169 reaction equation
[F:1][C:2]1([F:14])[O:6][C:5]2[CH:7]=[CH:8][C:9]([C:11]([OH:13])=O)=[CH:10][C:4]=2[O:3]1.O[N:16]=[C:17]([NH2:24])[C:18]1[CH:23]=[CH:22][CH:21]=[N:20][CH:19]=1.N>>[F:14][C:2]1([F:1])[O:6][C:5]2[CH:7]=[CH:8][C:9]([C:11]3[O:13][N:24]=[C:17]([C:18]4[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=4)[N:16]=3)=[CH:10][C:4]=2[O:3]1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 308113N-HydroxynicotinimidamideHCID 6087722,2-Difluoro-1,3-benzodioxole-5-carboxylic acid

Product 1

HCID 44544871HCID 44544871, compound

Procedure

The title compound was prepared according to Method C using 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylic acid (Aldrich) and N′-hydroxynicotinimidamide (Tyger). 1H NMR (300 MHz, DMSO-d6) δ 7.66 (ddd, J=8.1, 4.8, 1.0 Hz, 1H), 7.73 (d, J=8.5 Hz, 1H), 8.14 (dd, J=8.5, 1.7 Hz, 1H), 8.25 (d, J=1.7 Hz, 1H), 8.44 (dt, J=8.2, 1.9, 1.7 Hz, 1H), 8.82 (dd, J=4.7, 1.7 Hz, 1H), 9.25 (dd, J=2.2, 0.8 Hz, 1H) ppm; MS (DCI/NH3) m/z 304 (M+H)+.

Sources & evidence

ORD record
ord-0bf3a7df7a2940f2989530c1cf008543
Source dataset
uspto-grants-2015_05
Patent number
US09040568B2

Reaction notes

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