反应详情

温度

95 °C

A solution of 5-[1-(6-fluoro-2-pyridyl)pyrazolo[4,3-c]pyridin-6-yl]thiazole (50 mg, 0.17 mmol) and 1-N-boc-piperazine (175 mg, 0.921 mmol) in dimethyl sulfoxide; 2.0 mL was heated at 95° C. for 8 h. The reaction was quenched with water and extracted with EtOAc. The organic layers was dried with sodium sulfate, filtered, and concentrated in vacuum to give tert-butyl 4-[6-(6-thiazol-5-ylpyrazolo[4,3-c]pyridin-1-yl)-2-pyridyl]piperazine-1-carboxylate:

1. customThe reaction was quenched with water
2. extractionextracted with EtOAc
3. dry with materialThe organic layers was dried with sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated in vacuum