Ammonia → HCID 44545070, compound

HRID 578185Notes

Reaction equation

HRID 578185 reaction equation
[O:1]=[C:2]1[NH:6][C:5]2[CH:7]=[C:8]([C:11]([OH:13])=O)[CH:9]=[CH:10][C:4]=2[O:3]1.O[N:15]=[C:16]([NH2:23])[C:17]1[CH:22]=[CH:21][CH:20]=[N:19][CH:18]=1.N>>[N:19]1[CH:20]=[CH:21][CH:22]=[C:17]([C:16]2[N:23]=[C:11]([C:8]3[CH:9]=[CH:10][C:4]4[O:3][C:2](=[O:1])[NH:6][C:5]=4[CH:7]=3)[O:13][N:15]=2)[CH:18]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 308113N-HydroxynicotinimidamideHCID 64999892-Oxo-2,3-dihydro-1,3-benzoxazole-5-carboxylic acid

Product 1

HCID 44545070HCID 44545070, compound

Procedure

The title compound was prepared according to Method C using 2-oxo-2,3-dihydrobenzo[d]oxazole-5-carboxylic acid (Matrix) and N′-hydroxynicotinimidamide (Tyger). 1H NMR (300 MHz, CD3OD) δ 7.40 (d, J=8.5 Hz, 1H), 7.64 (ddd, J=8.0, 5.0, 0.9 Hz, 1H), 7.90 (d, J=1.7 Hz, 1H), 8.01 (dd, J=8.3, 1.9 Hz, 1H), 8.55 (dt, J=7.8, 1.9 Hz, 1H), 8.74 (dd, J=4.8, 1.7 Hz, 1H), 9.29 (dd, J=2.2, 0.9 Hz, 1H). ppm; MS (DCI/NH3) m/z 281 (M+H)+.

Sources & evidence

ORD record
ord-9f3f5a5e7bda46dcbb13b8cdd6e33445
Source dataset
uspto-grants-2015_05
Patent number
US09040568B2

Reaction notes

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