HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-Nitro-5-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3-Hydroxy-4-nitrobenzoic acid | HCID 69265 | — |
| Reactant | N-Hydroxynicotinimidamide | HCID 308113 | — |
| Product | 2-Nitro-5-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)phenol | HCID 67026095 | — |
Reaction Steps
The title compound was prepared according to Method C using 3-hydroxy-4-nitrobenzoic acid (Aldrich) and N′-hydroxynicotinimidamide (Tyger). 1H NMR (300 MHz, DMSO-d6) δ 7.67 (ddd, J=7.9, 4.8, 0.8 Hz, 1H), 7.76 (dd, J=8.5, 1.8 Hz, 1H), 7.92 (d, J=1.6 Hz, 1H), 8.12 (d, J=8.3 Hz, 1H), 8.45 (dt, J=7.9, 2.0 Hz, 1H), 8.83 (dd, J=4.8, 1.6 Hz, 1H), 9.26 (d, J=1.2 Hz, 1H)) ppm; MS (DCI/NH3) m/z 285 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09040568B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-b8e3d1dc3a5246a0a62f8fdcc2335ad8 |
| Source note | uspto-grants-2015_05 |