Furfurylamine → 2-chloro-5-fluoro-N4-(furfuryl)-4-pyrimidineamine

関与物質

役割	名称	HCID	仕込み量
反応物	Furfurylamine	HCID 3438	—
反応物	2,4-Dichloro-5-fluoropyrimidine	HCID 250705	—
反応物	2-chloro-5-fluoro-N-(3,4-ethylenedioxyphenyl)-4-pyrimidineamine	HCID 22060362	—
生成物	2-chloro-5-fluoro-N4-(furfuryl)-4-pyrimidineamine	HCID 22060737	—

反応手順

In a manner similar to the preparation of 2-chloro-N4-(3,4-ethylenedioxyphenyl)-5-fluoro-4-pyrimidineamine, 2,4-dichloro-5-fluoropyrimidine and furfuryl amine were reacted to yield 2-chloro-5-fluoro-N4-(furfuryl)-4-pyrimidineamine. 1H NMR (CDCl3): δ 7.91 (d, 1H, J=1.8 Hz), 7.39 (d, 1H, J=1.2 Hz), 6.35 (m, 2H), 5.50 (bs, 1H), 4.69 (d, 2H, J=5.1 Hz); 19F NMR (CDCl3): −45163; LCMS: ret. time: 24.52 min.; purity: 97%; MS (m/e): 228 (M+).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US09040550B2
出典データセット	uspto-grants-2015_05
ORD ID	ord-21c02406f0e84cca8e8e6fa1678d7488
出典メモ	uspto-grants-2015_05