反应详情

A solution of 3.6 parts of methyl 1-(2,3-dihydro-3-methyl-1H-inden-1-yl)-1H-imidazole-5-carboxylate mononitrate in 50 parts of a sodium hydroxide solution 20% is stirred for 1.5 hours at reflux temperature. After cooling, the reaction mixture is neutralized with acetic acid. The product is extracted with 1,1'-oxybisethane. The extract is dried, filtered and evaporated. The residue is crystallized from 2,2'-oxybispropane. The product is filtered off and dried, yielding 2.4 parts (90.0%) of 1-(2,3-dihydro-3-methyl-1H-inden-1-yl)-1H-imidazole-5-carboxylic acid; mp. 209.3° C. (compound 2.36).

1. temperatureat reflux temperature
2. temperatureAfter cooling
3. extractionThe product is extracted with 1,1'-oxybisethane
4. customThe extract is dried
5. filtrationfiltered
6. customevaporated
7. customThe residue is crystallized from 2,2'-oxybispropane
8. filtrationThe product is filtered off
9. customdried