Hexahydro-1,4-diazepine → 6-(5-cyclopropylpyridin-3-yl)-1-(6-(piperazin-1-yl)pyridin-2-yl)-1H-pyrazolo[4,3-c]pyridine

Participants

Reaction Steps

Following the procedures as described in EXAMPLE 8 and starting with 6-(5-cyclopropylpyridin-3-yl)-1-(6-fluoropyridin-2-yl)-1H-pyrazolo[4,3-c]pyridine and 1,4-diazepane, 112 was obtained as an off-white solid (30.9 mg, 22%). 1H NMR (400 MHz, DMSO) δ 9.37-9.25 (s, 1H), 9.04-8.98 (s, 2H), 8.67-8.59 (s, 1H), 8.51-8.45 (d, J=2.1 Hz, 1H), 8.05-7.99 (t, J=2.1 Hz, 1H), 7.74-7.66 (dd, J=14.5, 6.5 Hz, 1H), 7.24-7.15 (t, J=7.4 Hz, 1H), 6.65-6.58 (d, J=8.5 Hz, 1H), 3.90-3.73 (dt, J=10.0, 5.5 Hz, 4H), 3.00-2.91 (m, 2H), 2.75-2.65 (dd, J=13.3, 7.3 Hz, 2H), 2.12-2.04 (m, 1H), 1.91-1.81 (m, 2H), 1.12-1.03 (m, 2H), 0.88-0.81 (m, 2H).; MS (ESI) m/z: 412.2 [M+H]+

Provenance & Evidence