HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → 2-Tert-butyl-6-[(4-methylpiperazin-1-yl)thiocarbonylamino]-5-(4-methylpiperidin-1-yl)benzothiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 2-Tert-butyl-6-isothiocyanato-5-(4-methylpiperidin-1-yl)benzothiazole | HCID 15610362 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Tert-butyl-6-[(4-methylpiperazin-1-yl)thiocarbonylamino]-5-(4-methylpiperidin-1-yl)benzothiazole | HCID 19794198 | 95.1% |
Reaction Steps
To a stirred solution of 90 g of 2-tert-butyl-6-isothiocyanato-5-(4-methylpiperidin-1-yl)benzothiazole in 900 ml of methylene chloride is added dropwise 26 g of N-methylpiperazine. The solution is stirred for 1 hour, washed with water, dried over anhydrous sodium sulphate and evaporated to give 110 g of 2-tert-butyl-6-[(4-methylpiperazin-1-yl)thiocarbonylamino]-5-(4-methylpiperidin-1-yl)benzothiazole, melting at 192°-195° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05246927 |
| Source dataset | uspto-grants-1993_09 |
| ORD ID | ord-9fc75b912d0046a3a872e761ace84d22 |
| Source note | uspto-grants-1993_09 |