HRID57847
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 100 °C
PROCEDURE
实验过程
A mixture of 1-tert-butyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (220 mg, 0.88 mmol), tert-butyl 4-(6-(6-chloro-1H-pyrazolo[4,3-c]pyridin-1-yl)pyridin-2-yl)-1,4-diazepane-1-carboxylate (377 mg, 0.88 mmol), and Pd(dppf)Cl2 (64 mg, 0.088 mmol) in 1,4-dioxane (20 mL) and Na2CO3 (2.0 M, 5 mL) under nitrogen was heated at 100° C. for 20 hours. The crude product was purified by silica gel chromatography using petroleum ether:EtOAc (50%-100%) as eluting solvents to afford tert-butyl 4-(6-(6-(1-tert-butyl-1H-pyrazol-4-yl)-1H-pyrazolo[4,3-c]pyridin-1-yl)pyridin-2-yl)-1,4-diazepane-1-carboxylate as a yellow solid (240 mg, 53%). MS (ESI) m/z: 517 [M+H]+.
WORKUP
后处理
- customThe crude product was purified by silica gel chromatography
- washEtOAc (50%-100%) as eluting solvents