反应详情

To a solution of 3-amino-3-(3-nitrophenyl)propanoic acid (20.00 g; 95.15 mmol; 1.00 eq.) in MeOH (300 mL) was added thionyl chloride (50.00 ml; 761.22 mmol; 8.00 eq.) at 0° C. slowly. Then the mixture was warmed to room temperature and stirred overnight. The reaction mixture was evaporated and the crude product was purified by flash chromatography on silica gel (MeOH: DCM=15:85) to obtain 20 g of the title compound. LCMS [225 (M+1)].

1. customThe reaction mixture was evaporated
2. customthe crude product was purified by flash chromatography on silica gel (MeOH: DCM=15:85)