Ammonia → HCID 66762816, compound

HRID 578622Notes

Reaction equation

HRID 578622 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]([NH:18][C:19]2[C:28]3[C:23](=[C:24]([C:29]([O:31]C)=O)[CH:25]=[CH:26][CH:27]=3)[N:22]=[CH:21][N:20]=2)[CH2:11][CH2:12][N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[NH3:33]>CO>[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]([NH:18][C:19]2[C:28]3[C:23](=[C:24]([C:29]([NH2:33])=[O:31])[CH:25]=[CH:26][CH:27]=3)[N:22]=[CH:21][N:20]=2)[CH2:11][CH2:12][N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 66763306HCID 66763306, compound

Product 1

HCID 66762816HCID 66762816, compoundYield 81.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of methyl 4-{[1-(3-nitrophenyl)-3-pyrrolidin-1-ylpropyl]-amino}quinazoline-8-carboxylate (1 654.83 mg; 3.80 mmol; 1.00 eq.) and ammonia (16.29 ml; 7.00 M; 114.00 mmol; 30.00 eq.) in MeOH was stirred for 2 days. After concentration, the (1.3 g) of 4-{[1-(3-nitrophenyl)-3-pyrrolidin-1-ylpropyl]-amino}quinazoline-8-carboxamide was obtained.

Workup

  1. concentrationAfter concentration

Sources & evidence

ORD record
ord-49fe33a35af446a58685ccd4a57845f2
Source dataset
uspto-grants-2015_05
Patent number
US09040560B2

Reaction notes

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